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From the strong transcriptional strand bias of SBS-PolkKO mutations, we infer that the endogenous lesions driving mutation are adducts of guanine, which is line with the known in vitro biochemical activity of Pol of correctly inserting cytosine opposite N 2 -dG adducts 23,27
Yubero-Serrano et al
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[PubMed: 18519241] 413
Research demonstrates that glutathione supplementation can effectively increase body stores of this vital antioxidant
J.RubinJ.et al (1979)
