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Using these concentration we have not yet perceived any of the reported adverse affects, including hypoglycaemias, retinopathies or any others

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Ceramide activation of PKC leads to phosphorylation of PKB/AKT preventing PKB/AKT trafficking to the cellular membrane and insulin stimulation (197)

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More serious but rare adverse events include pancreatitis, gallbladder events, and hypoglycemia (primarily in patients using insulin simultaneously)
