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Unlike receptor-specific agonists, DSIP is investigated for its broader neuro-modulatory profile and interactions within hypothalamicpituitary signaling networks, making it of interest in sleep and endocrine research models

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Furthermore, 16S rRNA sequencing revealed a rebalancing of the gut microbiota, characterized by a reduced Firmicutes/Bacteroidota ratio, enrichment of beneficial taxa like Bacteroidota and Alloprevotella, suppression of pathobionts such as Desulfovibrionales, and partial restoration of microbial diversity
