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Stimulation of IGF1 production in liver has been considered to be a major effect of GH [47]

[DOI] [PubMed] [Google Scholar] 128.Xiao B, Li DD, Xu HX, et al

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Conversely, maximal uncoupled respiration, proton leak-related respiration, and non-mitochondrial oxygen consumption largely remain unaffected

Overall, HT pathogenesis results from a complex interplay between innate and adaptive immunity, where breakdowns in tolerance, skewed Th1/Th17/Treg balance, and persistent autoantibody production sustain chronic inflammation and irreversible thyroid destruction
