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FIGURE 3 3.4 Leukemic microenvironment Mounting evidence suggest that cancer-associated fibroblasts (CAFs) represent the predominant fraction of stromal cells inside the solid tumor microenvironment ( In addition to LAFs, the leukemic microenvironment also includes other stromal cells that support the survival of DTP cells by secreting cytokines and chemokines and offering physical support (Figure 4)