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Mechanistically, HIF-1 directly bound to the promoter of the ACSL4 gene and regulated ACSL4 transcription (Fig

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Michielsen et al., 2011), and poor plasticity of the central nervous system is thought to be responsible for some forms of sensory disturbance and chronic pain

The TRIUMPH-4 Phase 3 trial in obesity with knee osteoarthritis (Bays et al., NEJM 2025) reported 28.7% mean weight loss at 68 weeks at the 12 mg dose, plus a 75.8% reduction in WOMAC knee pain scores