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doi: 10.1006/bbrc.1999.0992 88 IshiguroT.MatsuoK.FujiiS.TakayanagiN

Furthermore, macrophage infiltration into adipose tissue exacerbates inflammation and insulin resistance, creating a vicious cycle of metabolic dysfunction (Alemany, 2024)

[DOI] [PMC free article] [PubMed] [Google Scholar] 80.Thundimadathil J

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Metabolic Alterations Induced by Chronic Alcohol Exposure The excess NADH generated by ethanol metabolism profoundly alters the hepatic metabolic profile: it inhibits mitochondrial -oxidation (via the accumulation of NADH and malonyl-CoA), activates de novo lipogenesis (through ACC, SREBP-1c, and ChREBP), suppresses gluconeogenesis (by shifting pyruvate toward lactate), and impairs oxidative phosphorylation by disrupting the Krebs cycle and electron transport chain [22,23]

Such an approach could also stimulate local economies and contribute to community resilience