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Mitochondrial GSH homeostasis is particularly important because, under pathological conditions, excessive generation of ROS results in toxic accumulation of GSSG [25]

doi: 10.1038/srep35165 35 DholpuriaSVyasSPurohitGNPathakKML

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Because these events are differentially regulated by the three limbs of the UPR, our data suggest that etomoxir diminishes signaling from all three UPR pathways

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