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Activation of the ERK pathway is one of the major targets of VEGFR-2 activation, and this link between ERK and VEGFR-2 is necessary for adipose mesenchymal stem cell (AMSC) to EC differentiation (186, 187)
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In breast cancer, CHAC1 overexpression promotes both proliferation and migration, while in ovarian cancer, its impact is primarily restricted to cell migration, with minimal effect on proliferation ( TP53, encoded by the TP53 gene and mutated in over 50% of human cancers, is essential for cell-cycle regulation and the induction of programmed cell death
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Genes (Basel) 12:1805
Asai H, Watanabe Y, Yamauchi-Kohno R, Doi O
