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Arch Gerontol Geriatr 42:289306 Mizutani K, Ikeda K, Nishikata T, Yamori Y (2000) Phytoestrogens attenuate oxidative stress DNA damage in vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats

doi: 10.1016/j.tjnut.2024.03.012

This means: No human PK reference data No human bioavailability data No human metabolism or clearance data Rodent-to-human PK extrapolation is therefore speculative This is a major context for research framing

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The enzyme in Histazyme, DAO, is not absorbed and does not have systemic activity