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AOD-9604 is a synthetic 16-amino-acid peptide corresponding to the C-terminal fragment (residues 177191) of human growth hormone, modified with an additional N-terminal tyrosine residue to improve stability

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Relative to rAmy bound to CTR, Cagri is likely to require extra energy to weaken the salt bridge to attain a CT-like state, thus providing a structural rationale for the smaller population of Cagri-bound particles sampling a CT-like conformation