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In addition, the intestinal microflora produces compounds that may enter the circulation

As the field progresses toward clinical implementation, it is crucial to recognize the constraints of existing experimental models

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Glutamine-derived 2-hydroxyglutarate is associated with disease progression in plasma cell malignancies

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We therefore propose that acidification of mutant supernatant (via secretion of acids and impaired urease activity) and changes to extracellular antioxidant composition circumvented the oxidation of L-DOPA, thereby preventing its use in melanin formation by gsh2 mutants