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11 Modafinil and armodafinil are FDA approved for use in narcolepsy and shift-work sleep disorder and have been noted to improve wakefulness/alertness and multiple sclerosisrelated fatigue, as well as residual daytime sleepiness in obstructive sleep apnea

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More serious deficiencies have the potential to impair heart and neurological function, leading to a wide range of serious symptoms, including but not limited to tinnitus, severe joint pain, memory problems, depression, anxiety, poor muscle function, ataxia and changes in reflexes

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Oral administration provides lower systemic exposure but is preferred for gastrointestinal targets