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In this process, copper contributes to neuronal damage and death via multiple mechanisms, closely tied to reactive oxygen species (ROS) production, mitochondrial dysfunction, and regulation of apoptotic signaling pathways (196)

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Neurosci Bull 26:6676 Yun SP, Kam T-I, Panicker N, Kim S, Oh Y, Park J-S, Kwon S-H, Park YJ, Karuppagounder SS, Park H (2018) Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinsons disease