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Recent advances in imaging, including contrast-enhanced MRI with intrathecal gadolinium tracers, allow in vivo assessment of glymphatic clearance efficiency [420]

Ottria et al

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doi: 10.1016/j.neuron.2018.06.030 105 El KarimI

Variants of other genes involved in homocysteine metabolism, such as MTHFR, 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR), MTR reductase (MTRR) and metabolism of cobalamin associated C, also contribute to homocysteine toxicity

162 When engineered to overexpress HIF-1 and telomerase (MSCs-T-HIF) and conditioned with proinflammatory stimuli, EVs (EV MSC-T- HIFCs ) with potent immunomodulatory activity are released