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In addition, the complexes can be reduced to their active platinum(II) species in the reductive/hypoxic environment of the malignant tissue, leading to a more tumor-specific activation

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In the contrary, the spectrum of protoporphyrin IX, a chemical moiety consisting of the tetrapyrrole ring lacking the iron atom, remains unaffected by the action of thiols

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[DOI] [PMC free article] [PubMed] [Google Scholar] Zheng H, Jiang M, Trumbauer ME, Sirinathsinghji DJ, Hopkins R, Smith DW, Heavens RP, Dawson GR, Boyce S, Conner MW, et al