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In addition, these animals develop glomerular hypertrophy, mesangial proliferation and matrix deposition at around 4 weeks

[DOI] [PubMed] [Google Scholar] 138.Portala K, Westermark K, von Knorring L & Ekselius L Psychopathology in treated Wilsons disease determined by means of CPRS expert and self-ratings

Administration of paclitaxel alone led to tumor reduction followed by tumor expansion, whereas CB-839 alone or in combination with paclitaxel reduced tumor growth with no tumor regrowth over time [42]

doi: 10.1038/nature09976 167 PetersC

Protein abundance changes (expressed in log 2 ) were calculated by linear mixed-effect model and tested for statistical significance using a two-sided t -test

3.6 Mitophagy impairment:PINK1 parkin and alternative pathways Mitophagy is a specialized form of autophagy essential for mitochondrial quality control, involving the selective sequestration of damaged mitochondria into autophagosomes for lysosomal degradation