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(2000), Horm Res 53(Suppl 3), PubMed 10971106 Statistics from preclinical literature AOD-9604 = modified fragment of hGH 177191 + N-terminal Tyr (sequence Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe), molecular weight 1815.1 Da Developed at Metabolic Pharmaceuticals (Australia) based on the work of professor Frank Ng (Monash University) in the 1990s Standard experimental dose in obesity clinical trials: 1 mg/day subcutaneously (Phase 2b, Heffernan et al.) Mechanism: stimulation of 3-adrenergic receptors in adipose tissue, increased lipolysis and fatty acid oxidation without activation of the hGH receptor (no IGF-1 increase) Phase 2b clinical trial (2007, 300 patients): weight reduction ~2.8 kg vs placebo over 12 weeks FDA status: NDI rejection (2014) as a dietary supplement

Unlike full growth hormone, it specifically targets fat cells without affecting blood sugar or promoting unwanted tissue growth

Its also a precursor to both methylcobalamin and adenosylcobalamin

Febuxostat (Uloric): this medication was approved by the FDA in February 2009 for treating patients with gout by lowering their uric acid levels

28.2% for controls (Pickart & Margolina, 2018)

Food and Drug Administration (FDA) doesnt require supplements to be proven safe or effective before theyre sold