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3.5.3 Epigenetic modulation A distinctive molecular action of ITCs, especially SFN, is the inhibition of histone deacetylases (HDACs)

6 The potential of ferroptosis in PD early diagnosis It is estimated that by the time motor deficits are detected and individuals with PD receive a clinical diagnosis, they may have lost 3050% of their dopaminergic neurons, accompanied by a 5060% reduction in striatal dopamine (212), underscoring the critical need for early diagnosis in PD treatment

This inherent protective quality is not confined to a single organ system but rather exerts a stabilizing influence across various tissues, providing the mechanistic foundation for its dual action in both the gastrointestinal tract and the central nervous system

Korteland-Van Male, H

RC (#304844/2022-5), PGC (#304855/2022-7), RF (#313633/2021-5), and DA (#308533/2018-6 and #313420/2023-8) thank CNPq for their research productivity fellowships

We further performed immunohistochemistry to confirm the astrocytic localization of SIRT2 and found significant elevation of SIRT2 intensity in the astrocytes (GFAP-positive area) of the hippocampal CA1, CA2, CA3, CA4, and DG in AD patients (Fig