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In tumor-associated epilepsies such as glioblastoma, xCT overexpression and elevated peritumoral glutamate concentration were associated with seizure generation and complications in patient survival [5961] while treatment with xCT inhibitors such as sulfasalazine decreased epileptiform activity in vivo and in vitro [62]

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[DOI] [PubMed] [Google Scholar] [15].de Macedo Andrade AC, Felix FA, Frana GM, Ribeiro ILA, Barboza CAG, de Castro RD, et al

Bottom line: For comparison, GLP-1 medications have evidence from STEP 1 (Wilding et al