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Conclusion Building on decades of research, the last 5 years have seen a flurry of novel discoveries enabled mostly by three key developments: (1) multi-omics approaches that integrate genetic, epigenetic, transcriptomic and proteomic profiling alongside high-resolution imaging and functional studies

doi: 10.1289/ehp.02110s5801 5 StepkaPVsianskyVRaudenskaMGumulecJAdamVMasarikM

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GSH levels and the GSH/GSSG ratio were reported to be higher in these individuals relative to those less-old (i.e., 6090 yrs), indicating that people who survive to reach the oldest-old category may have an overall more efficient antioxidant profile (Traverso et al., 2003)