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A similar result was achieved employing taurourso-deoxycholic acid [147] or the fatty acid analogue 2-(2-methoxyethoxy)ethyl 8-(cis-2-n-octylcyclopropyl) (A2C), a fluidizing agent, in the same model of ethanol-fed rats [68]

however, the other 2 trials concluded more recently (2019 and 2021) using pravastatin in combination with sorafenib showed no benefits in OS, and even the protective effects of sorafenib seem to disappear or be very subtle (Jouve et al., 2019

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It is becoming more widely acknowledged that ferroptosis, a newly identified kind of controlled cell death triggered by iron-dependent lipid peroxidation, plays a major role in the pathophysiology of ARDS ( Figure 2 )

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