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Accumulation of ROS can activate the mitochondrial apoptotic pathway and induce apoptosis, and esculetin can block this process by scavenging ROS (32)

Ultrastructural analysis revealed morphological characteristics indicative of ferroptosis in the HG and erastin cell groups, such as mitochondrial contraction, increased membrane density and reduced or absent mitochondrial ridges (Fig


However, in proteomic analysis, the phenylpropanoid biosynthesis pathway is significantly enriched only in the roots, not in the leaf tissue

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In addition, during vaso-occlusive episodes, SCD patients show distinct metabolite profiles from those at steady-state 7,8,9,10
