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& den Hartog, G

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1 Introduction Hepatocellular carcinoma (HCC) is the most frequent malignant tumor of the liver, with the highest occurrence among people with chronic liver disease (1) and a dismal 5-year survival rate

Drug Metab Dispos 42:2832 Coles B, Wilson I, Wardman P, Hinson JA, Nelson SD, Ketterer B (1988) The spontaneous and enzymatic reaction of N-acetyl-p-benzoquinonimine with glutathione: a stopped-flow kinetic study

HIF-1 is a transcriptional activator and a key regulator of the cellular adaptive responses to hypoxia and oxidative stress 25,26