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In the first, picroside II enabled an increase in cell viability and a reduction in glutamate-induced ROS

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To verify that the newly found metabolic reaction links to glutathione metabolism, we next treated cells with buthionine sulfoximine (BSO), which is an inhibitor of gamma-glutamylcysteine synthetase (GCS) in glutathione metabolism pathway 28

[DOI] [PMC free article] [PubMed] [Google Scholar] 166.Adibian M., Hodaei H., Nikpayam O., Sohrab G., Hekmatdoost A., Hedayati M

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