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Many animal studies [3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21,22,23,24,27,28,29,30,31,32,34,37,39,40], following the reported improved mild to moderate ulcerative colitis in patients, revealed considerable effectiveness in various models (ulcerative colitis, ulcerative colitis complicated with anastomosis, external and internal fistulas, short bowel syndrome)