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The inhibition of UPS results in the perturbation of intracellular protein homeostasisfundamental for cell function and viabilityby the accumulation of poly-ubiquitinated proteins, which subsequently induces cellular stress and apoptosis

No organ toxicity, no carcinogenicity signals, no reproductive toxicity have been demonstrated in animal models to date

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4.15.20 15mins said: The salicylates are one of the you really should avoid this, it can close some super important blood vessels before birth and that would be bad things

doi:10.1016/j.cccn.2005.05.023