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Description
Nuclear GAPDH also enhances the activity of the APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1) encoded enzyme (also referred to as AP site endonuclease 1, APE1) to promote the repair of damaged DNA
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2019 Zhu et al
E.LoebingerM
10.1111/and.12148 55
Yet, we find NE SCLC to also depend on anti-oxidant defense via the TRX pathway suggesting elevated ROS to also be a problem in this subtype
