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Once NAC promotes production of glutathione, glutathione is incorporated into crucial antioxidant enzymes (e.g., glutathione peroxidase and glutathione reductase) and detoxification enzymes (glutathione S-transferases)

Additionally, abnormal activation of LRRK2 downregulates SLC7A11 in microglia, impairing cystine import to inhibit GSH synthesis
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Protein Function & Thiol Regulation Glutathione contributes to the regulation of protein thiol-disulfide balance , influencing protein folding, stability, and signaling pathways

Ninomiya T, Kiyohara Y, Kubo M, Yonemoto K, Tanizaki Y, Doi Y, Hirakata H, Iida M
