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Detoxification: In the liver, glutathione conjugates with toxins, making them more water-soluble and easier to excrete through urine or bile

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Most of the biologically active T 3 in the circulation and inside cells is generated by the removal of one iodine atom from T 4 in a reaction catalyzed by selenium-dependent iodothyronine deiodinase enzymes

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It is not approved by the FDA for any indication and is available primarily through compounded sources without standardized regulatory oversight