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How AOD-9604 Burns Fat AOD-9604 works through two complementary mechanisms

This can convert apoptotic to necrotic cell death (Garcia-Ruiz and Fernndez-Checa, 2007)

226 Cu deficiency can also alter the expression of myocardial gene profile, for example by upregulating the inflammatory cytokine TNF- and genes involved in regulating cardiac contractility, fibrosis, and calcium cycling, all of which may underlie the changes in cardiac function under Cu-deficient conditions

doi: 10.1093/gerona/glr229

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This is exactly what has happened in the ME/CFS literature, where many different kit manufacturers have been used (see Table A1)