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An interesting approach when standard agents are either ineffective or poorly tolerated is the use of aprepitant
Four weeks of carnitine supplementation at 1 gram per day significantly increased weight loss in conjunction with a weight loss diet over the diet alone in a study of 100 obese subjects

Li L, Liu Y, Zhi N, Ji Y, Xu J, Mao G, et al
1 Restoring levels of key micronutrients like B12, folate, magnesium, zinc, iron, vitamin C, vitamin E, vitamin D, and selenium also supports neurological function, energy metabolism, and immune balance

2014;18 doi: 10.1093/ijnp/pyu1096

The prescription strength is orlistat 120 mg , taken three times daily
