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When we're lethargic, we're less likely to engage in physical activity, which can lead to reduced calorie expenditure

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Blocks NNMT in fat cells In 3T3-L1 mouse fat cells, 30 M of 5-Amino-1MQ for 24 hours strongly lowered 1-MNA levels direct proof of NNMT inhibition (Neelakantan et al., Biochemical Pharmacology, 2018)

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Over a comparable 68-week period, trial participants saw roughly a 16% reduction in body weight a substantially larger effect than liraglutide