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Various studies have described synthetic hydrogels (for example, polyisocyanide (PIC) 8 or polyethyleneglycol (PEG)) 9 , functionalized with integrin-binding motifs taken from ECM proteins

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Additionally, Nampt knockout mice models demonstrated that NAD + depletion in muscle leads to progressive loss of muscle function, while NR treatment restored mitochondrial function and induced muscle remodeling and restoration 255

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