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No serious systemic adverse events have been documented in peer-reviewed human studies at therapeutic doses

Proteins were injected intraperitoneally at the time of inoculation with 20 mg kg 1 cetuximab (3.33 nmol per animal), 2.2 mg kg 1 Albu-LiTE construct (500 pmol per animal) or 1.0 mg kg 1 LiTE (500 pmol per animal)

Using tissue from donors, the team observed that cells in the nucleus pulposus, a jelly-like structure at the center of intervertebral discs, had a lower amount of this peptide receptor when degeneration increased

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