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Abbreviations GSH glutathione SH sulfhydryl group O 2 superoxide H 2 O 2 hydrogen peroxide NOX NADPH oxidase SOD superoxide dismutase HOCl hypochlorous acid HOBr hypobromous acid Fe 2+ ferrous iron OH hydroxyl radical Fe 3+ ferric iron L lipid radical LOO hydroperoxide radical LOOH lipid peroxide HNE 4-hydroxy-2-nonenal ONOO peroxynitrite NO nitrogen oxide nitrite nitrate ONOOH peroxynitrous acid NO 2 nitrogen dioxide CFTR cystic fibrosis transport receptor GPx glutathione peroxidase PHGPx GPx IV phospholipid hydroperoxide glutathione peroxidase GSSG glutathione disulfide Prdx peroxiredoxin PSSG protein mixed disulfide PDI protein disulfide isomerase S thiolate PSOH sulfenic acid GST glutathione-S transferase GSNO nitrosoglutathione DTNB dithionitrobenzoic acid NEM N-ethylmaleimide NaBH 4 sodium borohydride OPT orthophthaldehyde GCL glutamate cysteine ligase ARE antioxidant response element JNK Jun N-terminal kinase GGT -glutamyl transpeptidase

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The rest is reabsorbed and metabolized

Biol Trace Elem Res 200(7):32363247 Rech L, Zahradka P (2024) Marginal zinc deficiency promotes pancreatic islet enlargement while zinc supplementation improves the pancreatic insulin response in Zucker diabetic fatty rats

These discrepancies between in silico and in vitro results could be a result of the fact that L-peptides are more prone to proteolysis compared to DRI forms