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Cholesterol and lipid profile: moderate evidence Alpha-lipoic acid (ALA) may help support a healthier lipid profile by reducing total cholesterol and triglyceride levels especially in individuals with metabolic disorders like type 2 diabetes or metabolic syndrome

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Low-dose naltrexone has shown beneficial effects when compared against a placebo after 12 weeks of treatment, with a mean difference of 0.34 on a 110 pain scale [45]