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In vitro assays revealed the interaction of TNBS with GSH leading to the almost instantaneous disappearance of GSH, while the reductive metabolism of TNBS by GSSG reductase generated ROS

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Antioxidants Like vitamin C & E with other plant extracts help scavenge free radicals that destroy skin cells

THP-1 and U937 monocytes were differentiated into macrophages, through which TNF and PGE-2 induced COX-2 and mPGES-1 expression by LDL could be analyzed on both mRNA and protein levels

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