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In some cases, doses of 1,000 to 2,000 mcg are common for treating B12 deficiencies

None of these have been documented in controlled studies

To minimize these confounding factors, matching, restriction, and stratification at the design phase is advised

For someone whose doctor has flagged elevated liver enzymes or fatty liver on an ultrasound, this distinction matters more than the headline weight loss numbers

Once researchers discovered methylene blue could safely act as a therapeutic agent, targeting specific biological processes within the body, the question quickly became: what else could it do

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