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Bax and Bak promote apoptosis by modulating endoplasmic reticular and mitochondrial Ca2+ stores

We have shown that effective pharmacologic inhibition of GPX4 in PTC cells with direct inhibitor RSL3 induces a robust activation of ferroptosis, increased DNA damage, impaired DNA damage repair response due to reduced p-NPM1 levels, decreased cell viability and cell migration, as well as suppressed spheroid formation and viability in vitro

Harrison, D

20, 55 As p53 abnormalities are associated with poor prognosis in MM, 2, 49 the ability of BSO+L-PAM to induce cell death by circumventing p53 loss-of-function may provide a viable therapeutic option for patients with del17p13 MM

Ecotoxicol Environ Saf 209:111790

Wang F, Wang J, Shen Y et al (2022b) Iron Dyshomeostasis and ferroptosis: a new Alzheimers disease hypothesis