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Slowly reducing B12 levels will impact the energy production in the mitochondria and the methylation pathways, affecting myelin production before it can create macrocytic anaemia (if ever)

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To further clarify the myeloid cells found in the final dataset, the nine myeloid cell clusters were subset out, re-clustered and re-embedded (Extended Data Fig

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However, subsequent analysis showed that 500mcg produced nearly identical results to 1mg in body composition changes