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In an effort to identify receptor residues that might interact with amino acids in this tripeptide sequence 24 hMC4R transmembrane (TM) residues were mutated (the rationale for choosing specific receptor residues for mutation is outlined in the Results section)

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Today it takes 150km to reach it which is a problem for the eventual stage winner as theyll have to cope with pushing a big gear for hours before finding their climbing legs to make their winning move

Swerdlow et al