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Likewise, anti-inflammatory actions of IGF-1 [124] can be regarded as a crucial factor protecting tissues from the deleterious effects of pro-inflammatory mediators in chronic disorders such as obesity

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Research has demonstrated that NAD+ availability directly influences the epigenetic landscape, with studies showing that NAD+ depletion leads to global changes in histone acetylation patterns and altered expression of genes involved in metabolism, stress responses, and aging

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Ginseng Res