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Abbreviations 2OG: 2-Oxoglutarate 3PG: 3-Phospho-glycerate 3PHP: 3-Phospho-hydroxypyruvate 5,10-CH 2 -THF: (6R)-5,10-methylenetetrahydrofolate ADP: Adenosine diphosphate ATP: Adenosine triphosphate DNA: Deoxyribonucleic acid -GC: -Glutamylcysteine GCS: Glutamylcysteine synthetase encoded Gly: Glycine GS: Glutathione synthetase GSH: Reduced glutathione GSSG: Oxidized glutathione H 2 S: Hydrogen sulfide l-Cys: L-cysteine l-Glu: L-glutamine LPS: L- O -phosphoserine l-Ser: L-serine NAD + : Nicotinamide adenine dinucleotide NADH: Reduced form of nicotinamide adenine dinucleotide PCR: Polymerase chain reaction Pi: Phosphate THF: Tetrahydrofolate References Meister A, Anderson ME

Antiarthritic effect of bee venom: inhibition of inflammation mediator generation by suppression of NF-kappaB through interaction with the p50 subunit

doi: 10.3390/ijms241310479 92 ZhaoLWangWHuangSYangZXuLYangQet al

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This level of glutamine accounts for over 20% of the total pool of free amino acids in the blood

discovered lactylation modifications on several metabolic enzymes, indicating that lactylation of these enzymes can provide negative feedback regulation on the glycolytic pathway