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It's a perennial

[DOI] [PMC free article] [PubMed] [Google Scholar] 228.Broyna A.A., Hoffman R.M., Slominski A.T

Some of the metabolic functions of BCAAs include a substrate for energy production, a substrate for protein synthesis, and a precursor for the formation of other amino acids such as alanine and glutamine, and serve as metabolic signals (primarily leucine), stimulating protein synthesis and leptin expression

Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA

The multifaceted regulation and functions of PKM2 in tumor progression

Transfection with Lipofectamine 2000 transfection reagent (Invitrogen, 11668027) was performed according to the manufacturers protocol
