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The issue to consider is that athlete in many sports have to ensure they abide by NGB rules ( eg

Reactive oxygen species generation by reverse electron transfer at mitochondrial complex I under simulated early reperfusion conditions

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Among these, nNOS is mainly found in the skeletal muscle and neural tissue, responsible for regulating local blood flow, while eNOS is primarily located in vascular endothelial cells, mainly responsible for regulating systemic blood flow (129)