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The ingredients and proximate composition of the basal diet are shown in Table 1

B12 is also added to certain foods, like cereals

Analysis of heavy metal content in Lentinula edodes and the main influencing factors

Clinical and serological study of myasthenia gravis using both radioimmunoprecipitation and cell-based assays in a South Asian population

At around 500mg/day, they are rarely reported, but as intake approaches 1,000mg/day or higher, gastrointestinal complaints become more likely.67 In one study, about 6% of patients at 1,000mg/day experienced GI issues, and a few discontinued the trial as a result.43 Still, research suggests these digestive side effects are often temporary, fading as the body adapts, especially when people start with smaller doses and build up gradually.37 67 Long-term use The best safety data come from ALS studies, where patients took 2,000mg/day (1g twice daily) for up to 18 months.38 42 Roughly 20% experienced gastrointestinal side effects, but most were able to continue by lowering their dose.67 Longer exposure has not been systematically studied, so the safety of multi-year supplementation remains unknown
