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The P53-inducible gene TIGAR codes for a protein that downregulates the cellular fructose-2,6-bisphosphate levels
Physical dependence on Adderall can develop after as few as 4 to 8 weeks of daily use exceeding therapeutic dosing thresholds, even in individuals who began using it for legitimate performance demands
N Engl J Med 344:350-362
Secondly, physical modifications in the receptor can also constitutively activate c-MET receptor through somatic mutations
