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266(1): 32938 Li DP, Chen SR, Pan YZ, et al

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Although soft tissue masses are not visible on plain film radiographs, these images can show secondary skeletal changes due to tumor mass effect or calcifications intrinsic to the tumor

Based on this framework, early studies often assumed MTNs, like TG neurons, were neural crest-derived ( Current consensus indicates that the majority of MTNs originate from the dorsal neuroepithelium at the midbrainhindbrain junction, encompassing the isthmic organizer region and the most rostral rhombomere ( Lineage-tracing studies using Cre recombinase systems driven by promoters active within this neuroepithelial territory, such as Wnt1 and Engrailed-1, have provided compelling evidence that progenitor cells expressing these transcription factors migrate from the ventricular zone and differentiate into MTNs (Zervas et al., 2004)