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These effects are correlated with a decreased astroglial reactivity and production of pro-inflammatory proteins, since ACEA did not impair A aggregation ( Similarly, CBD and THC have demonstrated neuroprotection in chronically treated APP/PS1 mice showing improvements in memory tasks and a decrease in soluble A42 levels, astrogliosis, and several neuroinflammation markers (Cheng D

However, an earlier review reported no improvement in reaction time, immediate memory or delayed recall in young adults with cognitive impairment

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Personalised models based on these proteomics data confirmed an increased pathway flux and CoASH in the model of an asymptomatic patient compared to those of symptomatic MCADD patients